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Peptides, growth factors, vitamin C, and hyaluronic acid are the ingredients experts say comprise the best wrinkle creams along with retinol. “[Formulas featuring] ingredients like retinol, growth factors, and peptides are going to take time to see improvement,” Marino says. “But overall, when you exfoliate and hydrate the skin, you will see less texture, more radiance, and more bounce to the skin, making it look more youthful.” Most importantly, make sure your skin is protected from harmful UV rays with consistent sunscreen use. “Doesn’t matter what wrinkle cream you are applying on your face at night,” Worden emphasizes. “If you aren’t applying SPF during the day to protect your skin, then you are wasting your time and money.”

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Thus, Worden explains that by incorporating these rejuvenating ingredients into your regimen, you can expect the following results: fewer wrinkles and fine lines, [even] toned skin, improved texture, dullness, hyperpigmentation, and elasticity. “If your goal is to avoid all wrinkles, I would recommend starting one when you see the first signs of wrinkles, which is usually in your 20s,” Greenfield notes. “A cream will not prevent the formation of all wrinkles, but it can boost collagen production, an important step in anti-wrinkle skin care.” As you can never be too cautious, start with one active ingredient product at a time when testing new additions, instead of opting for multi-action products.

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Shirazi shares a bit more helpful application guidance: “If you are starting a retinol, avoid or reduce your exfoliation until your skin gets acclimated. For those with sensitive skin, avoid a retinol with other potent actives like vitamin C or glycolic acid at the same time. Wait 2–4 weeks before adding one or the other. Some may not tolerate strong acids like glycolic or salicylic acid with a retinol. I suggest skipping the retinol the nights you exfoliate with a strong acid.” Read on to discover the best wrinkle creams our experts actually recommend—along with important ingredient callouts and application best practices. Greenfield recommends this moisturizer composed of 92% naturally derived ingredients to promote firmer and more supple skin without irritation. Skinbetter’s AlphaRet Overnight Cream is by far the most recommended wrinkle cream, with the stamp of approval from Hartman, Greenfield, Shirazi, and Marino. In short, experts love it because it works well while being gentle on skin. “It is a great retinol option for those who have had difficulty tolerating other retinols, and exfoliates in a gentle way,” Hartman explains. Because of this, Marino notes, “I can give this to the most reactive client, and they have no problem incorporating it into their routine.”

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